11 Best Regional Mexican Restaurants In Art District on Santa Fe

1. El Jefe

4.8

Exceptional(740)

$$$$

• Regional mexican • Highlands

Booked 1 time today

El Jefe in the Highlands of Denver is a standout gem for Farm-to-table enthusiasts. Renowned for its authentic Mexican cuisine, this restaurant goes beyond the ordinary by celebrating the vibrant flavors of Yucatán, Oaxaca, and Veracruz. The commitment to quality is evident in the way they "hand make tortillas every day" and "break down the whole hog" for various dishes, ensuring nothing goes to waste. Diners rave about the "fantastic quesa birria tacos" and the "best guac in town," highlighting the fresh, locally-sourced ingredients that define their menu. El Jefe is not just a meal; it's an experience rooted in respect for the land and tradition.

A photo of Blanco Cocina + Cantina - Denver restaurant

2. Blanco Cocina + Cantina - Denver

4.7

Exceptional(501)

$$$$

• Regional mexican • Mayfair

Booked 4 times today

Blanco Cocina + Cantina in Denver is not just a spot for delightful Mexican cuisine; it shines brilliantly as a Cocktail Bar. Guests rave about the "fantastic cocktails" and the "unique and delicious" drink offerings that elevate the dining experience to an art form. The vibrant atmosphere and expertly crafted margaritas are a perfect match for the tantalizing tequila flights that make this bar a local favorite. The "amazingly great" drinks, especially the well-balanced Spicy Margarita, have left patrons eager to return. For an unforgettable cocktail experience in Denver, Blanco Cocina + Cantina is the place to be!

A photo of Mister Oso Wash Park restaurant

3. Mister Oso Wash Park

4.6

Exceptional(313)

$$$$

• Regional mexican • Washington Park

Booked 25 times today

At Mister Oso we serve up family style latin food with rotating taco dishes, bright ceviches, house made churros, and award-winning coconut rice. Seasonal ingredients and creativity drive our menu and our talented chefs put passion into every bite. Come see us for daily Happy Hour featuring refreshing margaritas, frozen cocktails, Gordo Crunches and Death Bear Nachos. Our vibrant atmosphere lends itself perfectly to a night out with friends, casual date night, family gathering, or a weekend brunch get-together.

A photo of Blue Agave Grill - Denver restaurant

4. Blue Agave Grill - Denver

4.4

Awesome(1556)

$$$$

• Regional mexican • Downtown / LoDo

Booked 3 times today

Blue Agave Grill in Downtown Denver is a true gem for those craving authentic Southwest cuisine. Known for its vibrant atmosphere and from-scratch kitchen, it offers a delightful array of dishes that capture the essence of the Southwest with a contemporary twist. Diners rave about the "delicious authentic food" and the extensive gluten-free options, making it a standout for varied dietary needs. With a full bar boasting over 120 tequilas and an impressive selection of margaritas, Blue Agave Grill provides a complete Southwest experience. Guests consistently praise the "great food and drinks" and the friendly, attentive service, ensuring a memorable dining adventure.

5. Mister Oso - RiNo

4.5

Awesome(291)

$$$$

• Regional mexican • River North (Denver)

Booked 32 times today

Mister Oso - RiNo in Denver’s vibrant River North neighborhood is a haven for lovers of Traditional Mexican cuisine. Celebrated for “the highest quality fresh ingredients” and a menu that “never disappoints,” this lively spot offers an authentic taste of Mexico with a modern twist. Diners rave about the camarones and birria tacos, highlighting the “amazing” flavors that make each visit a memorable experience. With its “fantastic margaritas” and “FANTASTIC” service, Mister Oso stands out as a must-visit destination. Whether it's the enticing ceviche or the irresistible churros, this restaurant promises an unforgettable culinary journey that's sure to delight.

6. Otra Vez Cantina

4.5

Awesome(11)

$$$$

• Regional mexican • Downtown / LoDo

Booked 6 times today

Otra Vez Cantina brings bold Mexican flavors and vibrant energy to Denver’s iconic 16th Street Mall. With a name that means “once again,” Otra Vez is back — and better than ever — offering an elevated cantina experience that blends authentic Mexican cuisine with an upbeat, high-energy atmosphere.From handcrafted margaritas and a curated tequila / mezcal selection to a menu built around fresh, bold flavors, too keep you coming. Kick off your evening with our lively happy hour, featuring drink and bite specials that set the tone for a great night. Soak up the Colorado sun on our huge outdoor patio, complete with its own bar — one of the best spots on the 16th Street to enjoy a cold drink al fresco. On Saturday nights after dinner, our resident DJ keeps the energy high and bodies moving.Whether you’re stopping in for lunch, a festive dinner, or a night out, Otra Vez delivers the kind of experience that keeps guests coming back. Come for the food. Stay for the vibe. Come back “otra vez.”

7. Los Chingones

4.5

Awesome(24)

$$$$

• Regional mexican • Downtown / LoDo

Hi there! Wanted to circle back and let you that Los Chingones RiNo is open for carryout, delivery, indoor and outdoor seating! Our restaurant hours are: Closed on Monday; 3pm - 10pm on Tuesday; 11am - 10pm Wednesday and Thursday; 11am - 11pm Friday and Saturday; 11am - 10pm on Sunday. You can view the menu and place your order at https://www.loschingonesmexican.com/online-ordering/ or stop by the restaurant to dine in person!Please Note: this restaurant does not allow reservations as we are a walk-in restaurant only! NEW: Join our wait-list on Open-table so you're on the list before you arrive at the restaurant!!LOS CHINGONES, is Chef Owner Troy Guard’s Mexican concept. The space features a 90- seat rooftop bar and open main floor dining room, serving bold, flavorful, Guard-style twists on tapas style Mexican favorites. Los Chingones serves serves dinner Monday through Wednesday and lunch and dinner Thursday through Sunday.

8. Los Chingones DTC

4.6

Exceptional(314)

$$$$

• Regional mexican • Tech Center / Greenwood Village

Booked 1 time today

Los Chingones DTC does not take reservations outside of special events. Walk-ins are encouraged. See you soon!To order online for pickup and delivery, please visit loschingonesmexican.com!Los Chingones is Chef Troy Guard's take on "badass" Mexican: sassy, spicy and always an adventure.

9. Molino Chido

4.7

Exceptional(82)

$$$$

• Regional mexican • Aurora

Booked 11 times today

Molino Chido brings Mexico City taqueria aesthetics to Stanley Marketplace via award winning chefs Michael Diaz de Leon and Tommy Lee. Nixtimalized local corn is the base for the tortillas made in the windowed molino room for every taco. The menu is rounded out with shareable bites, large-format plates and an extensive beverage program of craft cocktails, natural wine, beer and non-alcoholic selections. Grab a green chair, sit back and enjoy the decidedly casual vibe with intentional sourcing, warm hospitality and cold bebidas.

10. El Coco Pirata

5.0

Exceptional(0)

$$$$

• Regional mexican • Denver

El Coco Pirata: A Taste of SinaloaWelcome to El Coco Pirata, your casual dining destination where culinary adventures await! Indulge in a vibrant selection of dishes featuring succulent meats, tender chicken, fresh seafood, and authentic Sinaloa-style sushi that will tantalize your taste buds. We are proud to be the Guinness World Record holder for the largest shrimp cocktail in the world in 2022, showcasing our commitment to extraordinary flavors and unforgettable experiences. Our full-service bar boasts an impressive lineup of mezcal, tequila, and whiskey, complemented by a variety of domestic and imported beers. Don’t miss out on our delicious Micheladas, perfect for enhancing your meal or kicking off your evening.Join us at El Coco Pirata and embark on a culinary journey filled with bold flavors, refreshing drinks, and a lively atmosphere — ideal for both family gatherings and special occasions. Come savor the essence of Sinaloa with us!

Best Regional Mexican Restaurants in Art District on Santa Fe

Price

Regions

Neighborhoods

Dining Options

Seating Options

Award-winning

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11 restaurants available nearby

1. El Jefe

2. Blanco Cocina + Cantina - Denver

3. Mister Oso Wash Park

4. Blue Agave Grill - Denver

5. Mister Oso - RiNo

6. Otra Vez Cantina

7. Los Chingones

8. Los Chingones DTC

9. Molino Chido

10. El Coco Pirata

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