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Best Southwest American Restaurants in South San Antonio

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142 restaurants available nearby

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A photo of King William Wine Company restaurant
1. King William Wine Company
new
4.7
Exceptional(13)
$$$$
• Mexican • Downtown
Booked 11 times today
King William Wine Co is an intimate wine-focused restaurant in San Antonio’s historic King William District, where exceptional wines, thoughtful cooking, and warm hospitality come together around the table.Created by Jill & Juan Arreguin, the restaurant reflects their belief that the best meals happen when great wine, beautiful food, and conversation are shared in the same place. Guests will often find the owners in the dining room, welcoming guests and sharing the stories behind the wines.Inspired by French and European traditions, the menu pairs naturally with a curated wine cellar featuring celebrated producers, rare bottles, and special large-format wines, alongside classic cocktails.Just minutes from Downtown San Antonio, The Alamo, and the River Walk, King William Wine Co offers a warm, inviting setting where guests gather to share exceptional wine and memorable meals. Recently named one of the Top 10 New Restaurants in San Antonio by the San Antonio Express-News.
A photo of Casa Hernán restaurant
2. Casa Hernán
new
(0)
$$$$
• Mexican • Downtown
The most profound influence on Chef Hernandez’s culinary style has been his extensive travels throughout Mexico. His time spent exploring the cultural nuances of each region’s art, agricultural, and street foods has shaped his vision to create authentic and accessible interior Mexican cuisine for American diners. His mission is to celebrate and preserve traditional Mexican food, ingredients and techniques. This mission serves as the guiding principle for creating unique dining experiences that reflect the rich and diverse flavors and culture of Mexico.
A photo of Camp Outpost Co. restaurant
3. Camp Outpost Co.
4.3
Awesome(4)
$$$$
• Mexican • Downtown
Booked 8 times today
Camp is a casual American dining experience that serves quality, rotisserie-driven comfort food with efficiency and flair. Centrally located in San Antonio's beloved Southtown, Camp features a custom world class rotisserie, a spacious patio and a communal fire pit evoking a nostalgic camp-like ambiance. Camp offers a fast-fine model of service which ensures swift ordering and attentive hospitality.
A photo of Chart House Restaurant - Tower of the Americas restaurant
4. Chart House Restaurant - Tower of the Americas
4.2
Awesome(16859)
$$$$
• Mexican • Downtown
Booked 161 times today
Chart House Restaurant - Tower of the Americas in Downtown San Antonio offers an exquisite American dining experience. Renowned for serving up fresh seafood and succulent steaks, the restaurant has been praised for its "absolutely fantastic" cuisine and service that goes "above and beyond." Guests rave about the cedar plank salmon and prime rib, describing their meals as "delicious" and "top tier." The stunning panoramic views from 750 feet in the air make dining here unforgettable. With a rich heritage of over 50 years, Chart House continues to redefine authentic American cuisine, making it a must-visit for both locals and visitors.
A photo of Domingo Restaurante restaurant
5. Domingo Restaurante
4.4
Awesome(1260)
$$$$
• Mexican • Downtown
Booked 100 times today
Join us in our open-air restaurant on the Historic San Antonio River Walk with a natural ambiance where curated contemporary art intersects with a historical setting. Domingo's menus offer the flavors of South Texas and an agave-forward beverage program celebrating the culture of San Antonio with modern culinary flair.
A photo of Bohanan's Prime Steaks and Seafood restaurant
6. Bohanan's Prime Steaks and Seafood
4.9
Exceptional(8625)
$$$$
• Mexican • Downtown
Booked 43 times today
Bohanan's Prime Steaks and Seafood in downtown San Antonio elevates seafood dining to an art form. Known for its "succulent seafood flown in fresh daily," the restaurant ensures that each dish bursts with authentic, ocean-fresh flavors. Diners rave about the "macadamia encrusted red snapper" and "outstanding salmon" that epitomize the exquisite quality of their seafood offerings. The AAA Four Diamond-rated restaurant pairs its seafood with impeccable service, creating an extraordinary dining experience. Located in a historic building near the River Walk, Bohanan's is a must-visit for seafood lovers seeking a memorable meal in a stunning, elegant setting.
A photo of Supper restaurant
7. Supper
4.7
Exceptional(3406)
$$$$
• Mexican • Downtown
Booked 58 times today
Supper, nestled in the heart of Downtown San Antonio, is a shining beacon of exquisite American cuisine. Housed within the historic Hotel Emma, this restaurant seamlessly marries South Texas hospitality with a modern flair. Diners frequently rave about the "sensational" food and "wonderful atmosphere," making it a favored spot for both locals and visitors alike. Whether enjoying a brunch with friends or a romantic dinner overlooking the river, Supper offers a diverse menu that guarantees satisfaction. The "divine" dishes and "attentive" service ensure that every meal is a memorable experience, solidifying Supper as a must-visit destination for authentic American dining.
A photo of Southerleigh Fine Food & Brewery restaurant
8. Southerleigh Fine Food & Brewery
4.7
Exceptional(3366)
$$$$
• Mexican • Downtown
Booked 50 times today
Southerleigh Fine Food & Brewery in Downtown San Antonio stands as a beacon of authentic American cuisine, blending coastal classics with comforting Southern flavors. Helmed by the talented Chef Jeff Balfour, the restaurant offers a dynamic, seasonally shifting menu that showcases his innovative craftsmanship. Diners rave about the "fantastic food," with standout dishes like the perfectly fried Snapper Throats and "best fried chicken in San Antonio." The brewery enhances the dining experience with its custom-crafted beers. Guests consistently praise the "outstanding service" and inviting atmosphere, making it a must-visit for anyone seeking a true taste of American culinary excellence.
A photo of Isidore restaurant
Icon
9. Isidore
4.7
Exceptional(502)
$$$$
• Mexican • Downtown
Booked 36 times today
Isidore, nestled in the heart of Downtown San Antonio, offers a remarkable journey into the world of Contemporary American cuisine. This vibrant eatery is celebrated for its "fantastic farm to market experience," showcasing the finest local Texas ingredients with a creative twist. The ever-changing menu ensures that each visit is a new adventure, with standout dishes like the "embered beets" and "Wagyu Ribeye" receiving rave reviews. Isidore's open kitchen concept adds a dash of theatrical flair to dining, while the robust wine list expertly curated by their sommelier perfectly complements each dish. This is a must-visit for those seeking an authentic and innovative dining experience.
A photo of Mezquite restaurant
10. Mezquite
4.6
Exceptional(443)
$$$$
• Mexican • Downtown
Booked 55 times today
Mezquite in Downtown San Antonio is a shining example of authentic Farm-to-table cuisine, celebrating the rich food pathways of the Sonoran region. This vibrant restaurant delights diners with expertly grilled meats and homemade flour tortillas. As one glowing review highlighted, "The food was some of the best Mexican food we have had and we are native to San Antonio." The dedication to fresh, quality ingredients is evident in every dish, from the savory elotes to the mouthwatering carne asada. With an inviting atmosphere and a menu full of savory delights, Mezquite promises an unforgettable dining experience perfect for any occasion.
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

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