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Restaurants near The Inn at Mayo Clinic

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129 restaurants available nearby

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A photo of M Brothers at Mayo restaurant
1. M Brothers at Mayo
4.9
Exceptional(637)
$$$$
• Seafood • Jacksonville
Booked 7 times today
M Brothers at Mayo is a hidden gem tucked inside Jacksonville’s Mayo Clinic—a delightful reprieve where culinary excellence meets refined hospitality. A Medure Brothers Culinary Concept by acclaimed chefs Matthew and David Medure, M Brothers is led by Executive Chef Thomas Rivers and offers a sophisticated dining experience on Mayo Clinic's campus.Enjoy globally inspired cuisine crafted with seasonal ingredients, and don’t miss our monthly Culinary Passport tasting menus, where we explore flavors from a different region of the world each month.Visit our lounge for a handcrafted cocktail or select a bottle from our extensive wine list. Join us for Lunch Monday–Friday and Dinner Monday–Saturday. Unwind during Happy Hour in the lounge, Monday–Friday from 4–6 PM. Whether you're sampling guest favorites like our burrata appetizer, savory shrimp étouffée, or a seasonal chef-driven entrée, M Brothers is a destination worth discovering.
A photo of Eleven South Bistro restaurant
2. Eleven South Bistro
4.8
Exceptional(4568)
$$$$
• Contemporary American • Jacksonville Beach
Booked 46 times today
At Eleven South, our food philosophy is simple – a taste for every palate and a palette for every season. Our menu is the centerpiece of the dining experience and features an exclusive variety of seafood, steaks, fresh fish and pasta dishes. Our open flame mesquite wood grill is our distinction and adds delectable flavor to many of our signature dishes from our signature Sea Bass to our steaks and appetizers.
A photo of Mezza Luna restaurant
3. Mezza Luna
4.8
Exceptional(2219)
$$$$
• Italian • Neptune Beach
Booked 52 times today
Locally owned and operated, we offer 3 different seating options:Standard seating: our formal dining room, perfect for date night, business dinners, gatherings with friends and family.Bar seating: tables in our lounge, family friendly, live music 6-9pm Sunday-Thursday.Outdoor Seating: covered patio, with fans in the summer and enclosed with heat in the winter. Family friendly and excellent for larger parties.In the interest of prompt and superior service, we do not split checks by item. Checks may only be split evenly. We encourage the use of Venmo. Reservations are recommended.
A photo of O-Ku - Jacksonville Beach restaurant
4. O-Ku - Jacksonville Beach
4.8
Exceptional(971)
$$$$
• Japanese • Jacksonville Beach
Booked 45 times today
O-Ku provides a fresh and innovative take on traditional Japanese sushi and cuisine. O-Ku's menu is comprised of signature starters, contemporary Japanese entrees and seasonal traditional sushi that reflect the uniquely designed space. The beachside location with waterfront and rooftop dining offers traditional sashimi and specialty rolls, sourcing seafood from the finest fish markets in Tokyo and Hawaii alongside local and seasonal ingredients.
A photo of Refinery Jax Beach restaurant
5. Refinery Jax Beach
4.4
Awesome(999)
$$$$
• American • Jacksonville Beach
Booked 45 times today
Welcome to Refinery Jax Beach—where unforgettable dining meets the ocean. Perfectly situated along the coast in beautiful Jacksonville Beach, we invite you to experience exceptional cuisine, handcrafted cocktails, and stunning views - all in one place.From elevated dining to a lively, more relaxed atmosphere, our four distinct spaces—Refined Dining, First Street Pub, Lounge, and Ocean Bar—offer something for every mood and occasion. Whether you’re here for a romantic dinner, brunch with friends, or a vibrant night out with live music, every visit is designed to feel special.Recognized by USA Today as one of the Top 15 Waterfront Restaurants in Florida, we take pride in delivering not just great food, but a complete experience—thoughtfully prepared dishes, warm hospitality, and an ambiance you’ll want to come back to again and again.Join us, unwind by the ocean, and let us take care of the rest.
A photo of Dwight's Bistro restaurant
6. Dwight's Bistro
4.9
Exceptional(1567)
$$$$
• French • Neptune Beach
Booked 13 times today
Dwight's Bistro, located in Jacksonville, Florida, features a unique blend of dishes from across Europe. The restaurant has private party rooms available for 12 or 20 people. Dwight's Bistro features a wine list that is available by the glass or by the bottle. The starters on the menu offered at Dwight's Bistro includes a chef's cheese plate, pan cooked foie gras and escargot. Chopped salad, Caesar salad and palm salad are offered as well. Entres are served with a vegetable and ravioli and feature veal piccata, filet mignon and crab cakes. Handmade pasta choices consist of fettuccini carbonara, veal sausage spaghetti, ravioli of the day and angel hair puttanesca.
A photo of Oaxaca Club restaurant
7. Oaxaca Club
4.5
Awesome(553)
$$$$
• Mexican • Jacksonville Beach
Booked 69 times today
Contemporary Mexican Cuisine in a modern setting. Curated Mezcal and Tequila menus to match authentic Oaxacan and regional Mexican food.At Oaxaca Club, each dish tells a story of ancient recipes and cooking techniques passed down through generations. From our traditional hand-made piquín, verde, and chipotle salsas, to our delicate Aguachile Amarillo with fresh serranos and quelites, to our hearty bone-in braised short-rib birria, we see it as our mission to capture the essence of Oaxaca's endless love affair with food, and bring a little piece of Oaxaca to you.Similar to wine, Mezcal reflects where it's grown; in Oaxaca's sun-soaked hills and rugged valleys, ancient agave plants absorb the region's rich volcanic soils, imbuing the spirit with a subtle earthiness. Our carefully curated menu is always evolving with the seasons, ensuring each visit brings the freshest and most vibrant flavors to your table and to those you share it with.
A photo of Argyle restaurant
8. Argyle
4.6
Exceptional(336)
$$$$
• Contemporary American • Ponte Vedra Beach
Booked 26 times today
Argyle is Ponte Vedra Beach’s award winning chef driven dining destination, where thoughtful sourcing, scratch made execution, and seasonal Contemporary American cuisine come together in a polished yet approachable setting. Led by Chef Blackford, recognized for his passion for technique, creativity, and elevating familiar flavors, each menu reflects an uncompromising commitment to quality. From house made breads, pastas, dressings, and desserts to signature dishes that blend refinement with comfort, Argyle offers an experience that feels both memorable and effortless. With elevated hospitality, seasonal evolution, and a setting designed to feel stylish yet welcoming, Argyle is helping redefine what dining in North Florida can be.
A photo of Coop 303 restaurant
9. Coop 303
4.3
Awesome(1272)
$$$$
• American • Atlantic Beach
Booked 27 times today
Coop 303 was born from a desire to prepare and serve delicious, and modern food paired with unique cocktails with genuine, caring hospitality — food and service from the heart.Coop 303 features curated dishes with a modern flavor and a classic feel. Two floors of dining and sipping with two unique rooms plus relaxing outdoor patios. Join us at our full-service downstairs bar where we showcase our classic and specialty cocktails, a variety of wines and an extensive whiskey collection.Coop 303 has a one-of-a-kind space on the top floor known as The Living Room Lounge which brings sexy sophisticated vibes of specialty cocktails and a live DJ to Atlantic Beach. Join us for dinner and work your way upstairs to enjoy all the experiences in one place.
A photo of Bonefish Grill - Jacksonville Beach restaurant
10. Bonefish Grill - Jacksonville Beach
4.5
Awesome(78)
$$$$
• Seafood • Jacksonville
Booked 57 times today
Your local Jacksonville Beach, FL Bonefish Grill® specializes in hand-cut, wood-grilled specialties and locally crafted Partner Selection dishes made with the freshest, highest-quality ingredients. The restaurant offers a selection of classic and signature hand-crafted cocktails, using just-squeezed juices, edible garnishes, and house infusions in addition to offering a distinct list of wines, which are the perfect match for any food pairing. In Jacksonville Beach on A1A

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Dining near The Inn at Mayo Clinic at a glance

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Most popular restaurant

popular restaurant

Izakaya Ko

5

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Exceptional reviews

Most popular cuisine

popular cuisine

Contemporary American

Average check amount

$30 and under

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From verified diners like you
From verified diners like you
  • Annette
    Jacksonville / Northeast Florida •1 review
    5.0
    Dined 2 days ago
    Joe was amazing server!! Highly recommend. The sashimi was perfection
    More info
    O-Ku - Jacksonville Beach$$$$• Japanese• Jacksonville Beach
    •
    4.8
  • OpenTable Diner
    Jacksonville / Northeast Florida •1 review
    5.0
    Dined 3 days ago
    Easy access to garage parking. Easy/direct access from the garage to the restaurant on the ground level of Mayo Clinic. Beautiful ambiance in the Mayo lobby. Wonderful decor/ambiance in the restaurant. Staff are very friendly, from the hostess to the waitress to the bartender in the lovely lounge area. The food was excellent - everything we ordered was craveable - appetizers, entrée, dessert - good wine selection. M Bros is a hidden gem in Jacksonville that I've enjoyed again and again. I highly recommend.
    More info
    M Brothers at Mayo$$$$• Seafood• Jacksonville
    •
    4.9
  • Cheryl
    Coastal Georgia •7 reviews
    5.0
    Dined 3 days ago
    Always great food! Always great service! Eleven South never disappoints!
    More info
    Eleven South Bistro$$$$• Contemporary American• Jacksonville Beach
    •
    4.8
  • mary
    Jacksonville / Northeast Florida •33 reviews
    5.0
    Dined 5 days ago
    Fabulous wine, fabulous food and fabulous service! Thank you!
    More info
    Mezza Luna$$$$• Italian• Neptune Beach
    •
    4.8
  • David
    New York City •22 reviews
    4.0
    Dined on Apr 29, 2026
    FIRST TIME THERE SINCE NEWLY OPENED. MEAL WAS EXCELLENT. SERVICE OK, MOSTLY FOOD TOOK A LONG TIME TO COME OUT. SERVER WAS FINE, THOUGH OBVIOUSLY NEW. WE WILL GO BACK FOR SURE..
    More info
    Refinery Jax Beach$$$$• American• Jacksonville Beach
    •
    4.4

Discover best restaurants near The Inn at Mayo Clinic

Experience comfort and convenience at The Inn at Mayo Clinic, a top choice for visitors to the Mayo Clinic in Jacksonville, Florida. Where to Eat Near The Inn at Mayo Clinic? The dining scene near The Inn is vibrant and diverse, offering something for every palate. Explore options ranging from sophisticated seafood dining with fresh catches to delightful French bistros that serve up classic dishes and exceptional wines. You can also enjoy Italian fare featuring handmade pastas, along with lively spots that offer a casual atmosphere perfect for gathering with friends or family. Whether you're savoring a delectable brunch or enjoying a romantic dinner, the nearby restaurants provide memorable culinary experiences that will complement your stay. Discover a culinary adventure just steps away from The Inn at Mayo Clinic.

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